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In Business 29 Years - Since 1980

THE CURRENT TIME at LC Labs is:  

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Eptaplatin
Product Number: E-4111
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: cis-malonato[(4R, 5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane] platinum(II)
Synonyms: Heptaplatin, HTP, Sunpla, SKI-2053R, NSC-D-644591, NSC-644591
Hazardous Ingredient: Eptaplatin
CAS Registry Number: 146665-77-2
Molecular Weight: 471.37
Molecular Formula: C₁₁H₂₀N₂O₆Pt

3. HAZARDS IDENTIFICATION:
Hazard Description:
Exposure may cause irritation of the respiratory tract, eye, and skin, and allergic respiratory and skin reaction
Potential birth defect hazard; pregnant women should avoid exposure
Ingestion may result in damage to the kidneys, liver, bone marrow, and reproductive system
Ingestion can cause nausea, vomiting, thrombocytopenia (abnormally low blood platelet level), azotemia (abnormally high blood urea nitrogen level), anemia, leukopenia (abnormally low white blood cell count), transient proteinuria (excessive protein in the urine), ascites (fluid buildup in the abdomen), abdominal pain, and elevated hepatic enzymes

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder, or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes, and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: Crystalline solid; granular or powder
Color: White to off-white
Odor: none
Melting point/Melting range: not tested
Danger of explosion: none
Solubility in / Miscibility with water: not tested
Solvent content: none
Organic solvents: not tested

10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS No: TP2505900
Acute toxicity: oral toxicity (LD50): 1590 mg/kg (mouse); i.p. toxicity (LD50): 198 mg/kg (mouse)
Primary irritant effect:
On the skin: not known; may be an irritant
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant; may be harmful if inhaled
Ingestion: harmful if swallowed

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
EU Risk And Safety phrases:
S22: Do not breathe dust

S36/37: Wear suitable protective clothing and gloves
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
R22: Harmful if swallowed
R61: May cause harm to the unborn child

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.