1. IDENTIFICATION OF SUBSTANCE:
Trade name: Erlotinib, Hydrochloride Salt
Product Number: E-4007
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Erlotinib, Hydrochloride Salt
Synonyms: CP-358774, OSI-774, Tarceva
Hazardous Ingredient: Erlotinib, Hydrochloride Salt
CAS Registry Number: 183319-69-9
Molecular Weight: 429.90
Molecular Formula: C22H23N3O4•HCl
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3. HAZARDS IDENTIFICATION:
Hazard Description: potential skin irritant; avoid contact with
skin, eyes; avoid inhalation; do not take internally
Effects of a ingestion may include lack of coordination, irregular breathing, diarrhea, nausea, headache, vomiting
and fatigue
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and
flush with copious amounts of water;
assure adequate flushing
by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: emits toxic fumes such as carbon
monoxide, etc.
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-
powdered liquid-binding material (diatomite, universal binders);
decontaminate surfaces and equipment by scrubbing with
alcohol; dispose of contaminated material according to Section
13.
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7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with
skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: off-white
Odor: none
Melting point/Melting range: 215 - 227 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in
water
Solvent content: none
Organic solvents: Soluble in DMSO/water 96/4, up to about 10
mg/mL (slight warming may be needed); very slightly soluble in
pure DMSO; very poorly soluble in ethanol
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10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing
agents
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide, carbon
dioxide, and nitrogen oxides
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11. TOXICOLOGICAL INFORMATION:
RTECS #:
Acute toxicity: none known
Primary irritant effect: none known
On the skin: none known
On the eye: not known; may be an irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state
and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Avoid breathing dust
Xn: Harmful
R22: Harmful if swallowed
R2: Risk of explosion by shock, friction, fire or other sources of
ignition.
R51: Toxic to aquatic organism
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all liability
for any damage resulting from use of this material. |
