1. IDENTIFICATION OF SUBSTANCE:
Trade name: Dasatinib
Product Number: D-3307
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Dasatinib
Synonyms: BMS-354825, Sprycel
Hazardous Ingredient: Dasatinib
CAS Registry Number: 302962-49-8
Molecular Weight: 488.02
Molecular Formula: C22H26CIN7O2S
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3. HAZARDS IDENTIFICATION:
Hazard Description: Toxic
May cause serious health effects if swallowed
May be harmful to fetus
Target organs: Gastrointestinal tract, blood, embryo/fetus
May be an irritant; exposure may cause irritation to eyes, skin,
mucous membranes, and upper respiratory tract
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and
flush with copious amounts of water; assure adequate flushing
by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: emits toxic fumes such as carbon
monoxide, etc.
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing and
heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with
finely-powdered liquid-binding material (diatomite, universal
binders); decontaminate surfaces and equipment by scrubbing
with alcohol; dispose of contaminated material according to
Section 13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with
skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: off-white to pale yellow
Odor: none
Melting point/Melting range: 261-285 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble
Solvent content: none
Organic solvents: very soluble in DMSO, up to about 200 mg/mL;
very poorly soluble in ethanol
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10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing
agents
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide, carbon
dioxide, and nitrogen oxides
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11. TOXICOLOGICAL INFORMATION:
RTECS #:
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state
and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S29: Do not empty into drains
S36/37/39: Wear suitable protective clothing, gloves, and
eye/face protection
S38: In case of insufficient ventilation, wear suitable respiratory
equipment
S45: In case of accident or if you feel unwell, seek medical
advice immediately (show label where possible)
S53: Avoid exposure - optain special instructions before
use
R25: Toxic if swallowed
R48/22: Harmful: danger of serious damge to health by
prolonged exposure if swallowed
R61: May cause harm to unborn child
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all liability
for any damage resulting from use of this material. |
