1. IDENTIFICATION OF SUBSTANCE:
Trade name: Docetaxel
Product Number: D-1000
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Docetaxel
Synonyms: Taxotere
Hazardous Ingredient:
Docetaxel
CAS Registry Number: 114977-28-5
Molecular Weight: 807.89
Molecular Formula: C43H53NO14
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3. HAZARDS IDENTIFICATION:
Hazard Description: may be an irritant; may cause irritation to
eyes, skin, mucous membranes
Information pertaining to particular dangers for man and
environment:
HMIS Ratings: Health =1 Flammability =0 Reactivity =0
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure
adequate flushing by separating the eyelids with fingers; call a
physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: may emit toxic fumes under fire
conditions
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing and
heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with
finely-powdered iquid-binding material (diatomite, universal
binders); decontaminate surfaces and equipment by scrubbing
with alcohol to remove bulk material; dispose of contaminated
material according to Section 13
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7. HANDLING AND STORAGE:
Information for safe
handling: avoid contact with skin, eyes and clothing; material
may be an irritant
Storage: store solid and solutions at -20 º
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline powder
Color: white
Odor: none
Melting point or range: 175-195 ºC
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content: none
Organic solvents: dimethyl sulfoxide (DMSO)
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10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide and carbon
dioxide
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11. TOXICOLOGICAL INFORMATION:
Acute toxicity: noneknown
Primary irritant effect:
On the skin: noneknown
On the eye: not known; may be an irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state
and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
Risk phrases: may be irritating to eyes, skin and respiratory
system
Safety phrases: in case of accident, flush eyes or skin with
copious amounts of water; remove contaminated clothing and
shoes; call a physician
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all liability
for any damage resulting from use of this material. |
