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Material Safety Data Sheet
Revision Date:  July 8, 2010

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Cyclosporin A
Product Number: C-6000
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Cyclosporin A
Synonyms: Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA, Sandimmune
Hazardous Ingredient: Cyclosporin A
CAS Registry Number: 59865-13-3
Molecular Weight: 1202.61
Molecular Formula: C62H111N11O12

3. HAZARDS IDENTIFICATION:
Hazard Description: potent immunosuppresant
RTECS Substance categories: Tumorigen; Drug; Mutagen; Reproductive effector
Exposure may cause irritation to eyes; mucous
membranes, upper respiratory tract and skin
Exposure may also cause the following: effect fertility and/or unborn child and breastfed infants;
lymphomas; convulsions; seizure or tremors; nutritional & gross metabolic changes; gastrointestinal
disturbances; cardiovascular changes; biochemical changes
Information pertaining to particular dangers for man and environment:
HMIS Ratings: Health =1 Flammability =0 Reactivity =0

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove conact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with skin, eyes, and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: white to off-white
Odor: none
Melting point/Melting range: 148-151ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 100 mg/mL; soluble in ethanol at 200 mg/mL

10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS#: GZ4120000
Acute toxicity: none known
Primary irritant effect:
On the skin: may be harmful
On the eye: may be an irritant

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Do not breathe dust
S23: Do not breathe vapour
S24/25: Avoid contact with skin and eyes
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
S60: This material and its container must be disposed of as hazardous waste
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R45: May cause cancer
R60: May impair fertility
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
R68: Possible risk of irreversible effects

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.


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Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.