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In Business 32 Years - Since 1980

THE CURRENT TIME at LC Labs is:  

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Capecitabine
Product Number: C-2799
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamic acid pentyl ester
Synonyms: Capecitabin, Capecitibine, Capecytabine, Capiibine, Captabin, Caxeta, 5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine, Ro 09-1978, Xabine, Xeloda
Hazardous Ingredient: Capecitabine
CAS Registry Number: 154361-50-9
Molecular Weight: 359.35
Molecular Formula: C₁₅H₂₂FN₃O₆

3. HAZARDS IDENTIFICATION:
Hazard Description: Toxic if swallowed or inhaled
May cause cancer
May be harmful to unborn child
Toxic to aquatic organisms, exposure may result in long-term adverse effects to aquatic environments
Exposure may cause adverse gastrointestinal, blood, and reproductive effects including suppression of bone marrow function, leukopenia (low white blood cell count), vomiting, diarrhea, nausea, loss of appetite, degeneration of the testes, and possible risk of impaired fertility
Exposure may cause irritation to eyes, mucous membranes, upper respiratory tract, and skin

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 113-125 ºC
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 2 mg/mL with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 100 mg/mL; soluble in ethanol at 12.5 mg/mL with slight warming

10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS No: HA3852500
Acute toxicity: oral toxicity (LD50): >2000 mg/kg (rat)
Primary irritant effect:
On the skin: not known; may be an irritant
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant
Ingestion: toxic if swallowed; may result in fetal harm and impaired fertility

12. ECOLOGICAL INFORMATION:
General notes: strictly avoid contamination of the environment

13. DISPOSAL CONSIDERATION:
Place material in a thick plastic hazardous waste disposal bag or leakproof container and label it CAUTION: HAZARDOUS CHEMICAL WASTE
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
UN number: 3077
DOT:
IATA: Environmentally hazardous substances, solid, n.o.s. (Capecitabine)
IMO: Environmentally hazardous substances, solid, n.o.s. (Capecitabine), 9, III
ADR/RID: Environmentally hazardous substances, solid, n.o.s. (Capecitabine), 9, III

15. REGULATIONS:
Code letter and hazard designation of product:
T: Toxic
N: Dangerous to the environment
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
S61: Avoid release to the environment. Refer to special instructions/Safety data sheets
R36/38: Irritating to eyes and skin
R45: May cause cancer
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R61: May cause harm to the unborn child

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.