1. IDENTIFICATION OF SUBSTANCE:
Trade name: Bisindolylmaleimide XI,
Hydrochloride Salt
Product Number: B-8777
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride
Synonyms: Ro 32-0432, BIM XI
Hazardous Ingredient:
Bisindolylmaleimide XI, Hydrochloride Salt
CAS Registry Number: 151342-35-7
Molecular Weight: 489.02
Molecular Formula: C28H28N4O2•HCl
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3. HAZARDS IDENTIFICATION:
Hazard Description: may be an irritant; exposure
may cause irritation to eyes, skin, mucous membranes, and
upper respiratory tract
Information pertaining to particular dangers
for man and environment:
HMIS Ratings: Health =1 Flammability =0
Reactivity =0
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to
fresh air; if breathing is difficult, give oxygen; if
breathing stops, give artificial respiration
After skin contact: flush with copious
amounts of water; remove contaminated clothing and shoes;
call a physician
After eye contact: flush with copious
amounts of water; assure adequate flushing by separating
the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out
mouth with copious amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water
spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear
self-contained breathing apparatus and protective
clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic
fumes under fire conditions
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety
precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing
and heavy rubber gloves
Measures for cleaning/collecting: absorb
solutions with finely-powdered liquid-binding material
(diatomite, universal binders); decontaminate surfaces
and equipment by scrubbing with alcohol; dispose of
contaminated material according to Section 13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid
contact with skin, eyes and clothing; material may be an
irritant
Storage: store solid and solutions at
-20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal
protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved
respirator
Protection of hands: chemical-resistant rubber
gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline
solid
Color: orange
Odor: none
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water:
not soluble
Solvent content: none
Organic solvents: soluble in DMSO
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10. STABILITY AND REACTIVITY:
Stability:
avoid acids and bases
Thermal decomposition / conditions to be
avoided: protect from light and heat
Dangerous products of decomposition:
thermal decomposition may produce toxic gases such as
carbon monoxide and carbon dioxide
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11. TOXICOLOGICAL INFORMATION:
Acute toxicity:
none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an
irritant
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12. ECOLOGICAL INFORMATION:
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13. DISPOSAL CONSIDERATION:
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this
substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this
substance is considered to be non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves and
eye/face protection
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16. OTHER INFORMATION:
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