1. IDENTIFICATION OF SUBSTANCE:
Trade name: Brefeldin A
Product Number: B-8500
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: γ-4-Dihydroxy-2-[6-hydroxy-1-heptenyl]-4-cyclopentanecrotonic Acid λ-Lactone
Synonyms: Acotoxin, BFA, Cyanein, Decumbin
Hazardous Ingredient: Brefeldin A
CAS Registry Number: 20350-15-6
Molecular Weight: 280.36
Molecular Formula: C16H24O4
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3. HAZARDS IDENTIFICATION:
Hazard Description: may be an irritant; exposure may cause
irritation to eyes, skin, mucous membranes, digestive tract, and
respiratory tract
Information pertaining to particular dangers for man and
environment: May be harmful by ingestion, inhalation, or
absorption through skin.
HMIS Ratings: Health =1 Flammability =0 Reactivity =0
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure
adequate flushing by separating the eyelids with fingers; call a
physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: may emit toxic fumes under fire
conditions
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing and
heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with
finely-powdered liquid-binding material (diatomite, universal
binders); decontaminate surfaces and equipment by scrubbing
with alcohol; dispose of contaminated material according to
Section 13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and
clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form:
Color:
Odor:
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content: none
Organic solvents: soluble in DMSO or ethanol
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10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide and carbon
dioxide
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11. TOXICOLOGICAL INFORMATION:
RTECS #: GY8410000
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal,
state and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered
to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered
to be non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves, and
eye/face protection
S45: In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible)
R20/21/22: Harmful by inhalation, in contact with skin, and if
swallowed
R68: Possible risk of irreversible effects
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all
liability for any damage resulting from use of this
material. |
