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Material Safety Data Sheet
Creation Date:  August 5, 2010

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Bimatoprost
Product Number: B-2777
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[1(E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide
Synonyms: AGN 192024, Latisse, Lumigan, Prostamide
Hazardous Ingredient: Bimatoprost
CAS Registry Number: 155206-00-1
Molecular Weight: 415.57
Molecular Formula: C25H37NO4

3. HAZARDS IDENTIFICATION:
Hazard Description: Harmful if swallowed or inhaled
May be harmful to unborn child
Ingestion may cause adverse gastrointestinal effects
Inhalation may cause headache, changes in blood pressure, and bronchoconstriction resulting in coughing, wheezing, and shortness of breath
Exposure may cause irritation to eyes, mucous membranes, upper respiratory tract, and skin

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 63-77 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 100 mg/mL; soluble in ethanol at 200 mg/mL

10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
To the best of our knowledge, the chemical, physiological and toxicological effects of this material have not been fully investigated
RTECS No: not available
Acute toxicity: oral toxicity (LD50): >250 mg/kg (mouse/rat)
Primary irritant effect: not known
On the skin: not known; may be an irritant
On the eye: not known; may be an irritant
Inhalation: not known; may be an irritant; harmful if inhaled
Ingestion: not known; may be an irritant; harmful if swallowed; possible risk of fetal harm

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
Xn: Harmful
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
R20/22: Harmful by inhalation and if swallowed
R63: Possible risk of harm to the unborn child

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.


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Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.