1. IDENTIFICATION OF SUBSTANCE:
Trade name: Bortezomib
Product Number: B-1408
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Bortezomib
Synonyms: Velcade, MG-341, PS-341
Hazardous Ingredient: Bortezomib
CAS Registry Number: 179324-69-7
Molecular Weight: 384.24
Molecular Formula: C19H25BN4O4
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3. HAZARDS IDENTIFICATION:
Hazard Description:
Toxic. Contains a pharmaceutically active ingredient.
Handling should only be performed by personnel trained and
familiar
with handling of potent active pharmaceutical
ingredients
Moderate to severe irritant to the skin and eyes
Toxic by inhalation
Very toxic by ingestion
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and
flush with copious amounts of water; assure adequate flushing
by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: emits toxic fumes such as carbon
monoxide, etc.
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing and
heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-
powdered liquid-binding material (diatomite, universal binders);
decontaminate surfaces and equipment by scrubbing with
alcohol; dispose of contaminated material according to Section
13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with
skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: white to beige
Odor: none
Melting point/Melting range: 109 - 133 ºC
Danger of explosion: none
Solubility in / Miscibility with water: poorly soluble in aqueous
solution - maximum concentration recommended when diluting
into aqueous media is 100-200 µg/mL
Solvent content: none
Organic solvents: soluble in DMSO or ethanol; up to 200
mg/ml
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10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing
agents
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide, carbon
dioxide, and nitrogen oxides
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11. TOXICOLOGICAL INFORMATION:
RTECS #:
Acute toxicity: none known
Primary irritant effect: not known
On the skin: none known
On the eye: not known; may be an irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state
and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty
of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of
water
S36/37/39: Wear protective clothing, gloves and eye/face
protection
R28: Very toxic if swallowed
R38: Irritating to skin
R41: Risk of serious damages to eyes
R48: Toxic; danger of serious damage to health by prolonged
exposure
R62: Possible risk of impaired fertility
R63: Possible risk of harm to unborn child
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all liability
for any damage resulting from use of this material. |
